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Sildenafil (compound UK-92,480) was synthesized by a group of pharmaceutical chemists working at Pfizer's Sandwich, Kent research facility in England. It was initially studied for use in hypertension (high blood pressure) and angina pectoris (a symptom of ischaemic cardiovascular disease). The first clinical trials were conducted in Morriston Hospital in Swansea.[2] Phase I clinical trials under the direction of Ian Osterloh suggested that the drug had little effect on angina, but that it could induce marked penile erections.[1][2] Pfizer therefore decided to market it for erectile dysfunction, rather than for angina. The drug was patented in 1996, approved for use in erectile dysfunction by the Food and Drug Administration on March 27, 1998, becoming the first pill approved to treat erectile dysfunction in the United States, and offered for sale in the United States later that year.[3] It soon became a great success: annual sales of viagra 1 pound 20 pence in the period 1999–2001 exceeded $1 billion.
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The British press portrayed Peter Dunn and Albert Wood as the inventors of the drug, a claim which Pfizer disputes.[4] Their names are on the manufacturing patent application drug, but Pfizer claims this is only for convenience.
viagra 1 pound 20 pence is known as a PDE5 inhibitor, just as Cialis and Levitra are.
All three erectile dysfunction drugs work by allowing the blood vessels that supply the penis with blood to relax, which increases blood flow during sexual stimulation. Greater blood flow leads to harder erections that last longer. Without sexual stimulation, viagra 1 pound 20 pence will not cause an erection to occur. And when the stimulation is ended, the erection will go away. viagra 1 pound 20 pence works in most men regardless of how old they are or how long they've had ED.
Even though sildenafil is available only by prescription from a doctor, it was advertised directly to consumers on U.S. TV (famously being endorsed by former United States Senator Bob Dole and football star Pelé). Numerous sites on the Internet offer viagra 1 pound 20 pence for sale after an "online consultation," often a simple web questionnaire. The "viagra 1 pound 20 pence" name has become so well known that many fake aphrodisiacs now call themselves "herbal viagra 1 pound 20 pence" or are presented as blue tablets imitating the shape and colour of Pfizer's product.
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viagra 1 pound 20 pence is taken one hour before sexual activity. Some form of sexual stimulation is needed for viagra 1 pound 20 pence to work.
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For most men, the recommended initial dose of viagra 1 pound 20 pence is 50 mg but depending on your individual tolerance, the dosage may be increased up to 100 mg or decreased to 25 mg. Do not take viagra 1 pound 20 pence more than once daily. Do not take viagra 1 pound 20 pence within 24 hours of taking any other ED prescription medication.
Taking viagra 1 pound 20 pence with a high fat meal may reduce its absorption and effectiveness. viagra 1 pound 20 pence does not protect against sexually transmitted diseases.
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In February 2007, it was announced that Boots the Chemist would trial over the counter sales of viagra 1 pound 20 pence in stores in Manchester, England. Men aged between 30 and 65 would be eligible to buy four tablets after a consultation with a pharmacist.[5]
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Pfizer's worldwide patents on sildenafil citrate will expire in 2011–2013. The UK patent held by Pfizer on the use of PDE5 inhibitors (see below) as treatment of impotence was invalidated in 2000 because of obviousness; this decision was upheld on appeal in 2002.
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